Although Airflo is generally considered safe, it is important to note certain precautions before use. If you experience difficulty breathing through your nose, it is advised not to use Airflo. Furthermore, if you are obese with a BMI over 35, it should not be used as a standalone solution without a CPAP device. It is also not recommended for individuals with very low blood pressure, severe heart or breathing problems, or those currently dealing with a cold, sinus, or ear infection. Additionally, refrain from using Airflo if you have severely chapped lips or any non-intact skin surrounding the mouth area. Lastly, it is advisable to avoid using Airflo mouth tape after consuming alcohol or sedatives.